Capture and recovery of antibodies and cells


Monoclonal – and polyclonal antibodies

Monoclonal antibodies (mAbs) are the most accelerating drug products on the market. With an increasing demand of mAbs, a significant burden has been placed on the mAbs capture and downstream process. The Protein A column chromatography process, which can reach over 90% purity, is the overall golden standard process for the purification of mAbs. However, before the Protein A column capture step, the cells producing the mAbs needs to be removed by filtration or centrifugation in order to prevent column clogging issues. This step will decrease the overall yield, is costly, can take many hours, and also to increase host cell protein (HCP) levels and proteolytic activity in the clarified material, due to cell lysis demanding following challenging purification steps. 


Our MAGic methodology is a one-step batch separation product-recovery process, directly applied on the cell broth, and provides increased product yield and savings in terms of time, material, and other resources, while also reducing the HCP levels. The methodology includes a magnetized resin, our MAGicBeads dedicated for mAb capture, together with specially designed magnetic separators, our MAGicSep units, optimized for efficient separation of the magnetized resin. Our products gives unique scalability for the lab, pilot and the process scale.

Our MAGicBeads also seamlessly integrate with commercial high-throughput automation systems

Our products dedicated for antibodies

MAGic™Beads mAb
MAGicBeads mAb is a magnetic bead coupled with an alkali resistant protein A ligand optimized for purification of mAbs directly from the cell broth. The high bindning capacity, stability of the matrix and alkali resistance of the ligand makes the resin suitable for repeated purification cycles without loosing performance when cleaning with 0.1-0.2M NaOH between the runs.

MAGic™Beads custom
MAGicBeads is an agarose-based magnetic bead coupled with an recombinant protein A ligand for capture and recovery of monoclonal and polyclonal antibodies directly from complex feedstocks.

MAGic™Beads SerA
MAGicBeads SerA are optimized for the purification of polyclonal antibodies from serum and monoclonal antibodies from ascites fluid samples. The magnetic beads have a binding capacity of 60 mg human or rabbit IgG per ml settled beads.

MAGic™Accio Lab, Pilot and Process
The MAGicSep Lab and Pilot units are designed for durability with a lacquered plastic shell and nickel plated neodymium magnets placed safely inside. They fit standard test tubes and are available in sizes from 1 ml to liters. The MAGicSep Process units are made for efficient capture of 1-40 liters of MAGicBeads from thousands of litres of complex feedstocks.


Today several projects within therapy are based on using viable cells as personalized medicines and these cells have to be pure and active. The separation and sorting processes of the cells is thus of critical nature.

 Numerous cell isolation and sorting techniques have been developed for benchtop and clinical settings that are based on either physical properties of the cell or on cell-surface affinity. Standard separation techniques based on the cells physiological properties include filtration, centrifugation and sedimentation. However, in the field of cell therapy the cell size or density differences are not significant and effective cell separation is hindered. Therefore other methods are used.

Isolation techniques that are based on the cell-surfaces antigen binding such as fluorescence activated cell sorting (FACS) and magnetic activated cell sorting (MACS) is now popular and attractive. Because of its specificity, flexibility, ease-of-use and scalability MACS is currently the technique with the greatest potential for cell separation in the cell therapy field. Until now, effective magnetic-based cell separation methodologies are present for up to 100ml sample volumes.

Our novel MAGic methodology including magnetized resins and magnetic separators for all scales of purification of cells for therapy use. The technique offers a unique scalability from the lab bench through pilot and to the final process scale.


Our products dedicated for cells

MAGic™Beads ACT
Surface activated magnetic beads for covalent couplig of antibodies. By coupling cell-surface antigen active antibodies, the magnetic beads can be used both in positive selection and in negative selection (untouched) approaches of cell separation. We offer customized covalent coupling service of antibodies to the activated beads.

MAGic™Accio Lab, Pilot and Process
Our magnetic separators (MAGicSep) gives unique scaleability for the lab, pilot and the process scale.